Tissue Factor Gene Expression Analysis in Circulating Monocytes*
نویسندگان
چکیده
منابع مشابه
Basic fibroblast growth factor increases tissue factor expression in circulating monocytes and in vascular wall.
BACKGROUND Basic fibroblast growth factor (bFGF) promotes vascular repair and angiogenesis and can induce in vitro tissue factor (TF), a potent agent initiating thrombogenesis, which probably plays a role in angiogenesis. We investigated whether bFGF administration induced TF expression by monocytes and vascular cells. METHODS AND RESULTS We studied TF expression in normally fed (n=16) and ch...
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Accelerated coronary atherosclerosis in cardiac allografts is the major limiting factor for long-term survival after heart transplantation. There is growing evidence that activation of the coagulation mechanism is involved in the development of transplant atherosclerosis. Tissue factor (TF) expression by cells of the monocyte/macrophage system may represent an important mechanism underlying the...
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http://bloodjournal.hematologylibrary.org/content/91/8/2857.full.html Updated information and services can be found at: (2497 articles) Hemostasis, Thrombosis, and Vascular Biology Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in ...
متن کاملRetinoic acid selectively inhibits lipopolysaccharide induction of tissue factor gene expression in human monocytes.
Expression of tissue factor (TF) by activated monocytes in several diseases leads to disseminated intravascular coagulation. Lipopolysaccharide (LPS)-induced monocyte TF expression is downregulated by the nuclear hormone all-trans retinoic acid (ATRA). In this study, we examined the mechanism by which ATRA inhibits monocyte TF expression. We show that ATRA selectively inhibited LPS induction of...
متن کاملTissue factor expression of human monocytes is suppressed by lysophosphatidylcholine.
The expression of tissue factor (TF), the principal initiator of coagulation, is increased during inflammation and atherosclerosis. Both conditions are promoted by lysophosphatidylcholine (lysoPC). We observed in the present study that lysoPC (1 to 10 micromol/L) dose-dependently reduced TF activity in human monocytes, as elicited by lipopolysaccharide (LPS). Lysophosphatidylethanolamine (lysoP...
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ژورنال
عنوان ژورنال: Transfusion Medicine and Hemotherapy
سال: 2006
ISSN: 1660-3796,1660-3818
DOI: 10.1159/000091110